Infinium MethylationEPIC Kit

Robust methylation profiling microarray with extensive coverage of CpG islands, genes, and enhancers. Use for epigenome-wide association studies. Read More...
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Infinium MethylationEPIC BeadChip Kit (16 samples)

WG-317-1001

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Infinium MethylationEPIC BeadChip Kit (32 samples)

WG-317-1002

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Infinium MethylationEPIC BeadChip Kit (96 samples)

WG-317-1003

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Product Highlights

With the Infinium MethylationEPIC BeadChip Kit, researchers can interrogate over 850,000 methylation sites quantitatively across the genome at single-nucleotide resolution. Multiple samples, including FFPE, can be analyzed in parallel to deliver high-throughput power while minimizing the cost per sample.

Infinium HD array technology enables content selection independent of bias-associated limitations often associated with methylated DNA capture methods. The result is a pan-enhancer and coding region view of the methylome that can be used for epigenome-wide association studies on a variety of human tissues.

Comprehensive Genome-Wide Coverage

This kit includes content categories requested by methylation experts, such as:

  • CpG sites outside of CpG islands
  • Non-CpG methylated sites identified in human stem cells (CHH sites)
  • Differentially methylated sites identified in tumor versus normal
  • FANTOM5 enhancers
  • ENCODE open chromatin and enhancers
  • DNase hypersensitive sites
  • miRNA promoter regions
Integrated Analysis Software

MethylationEPIC data analysis is supported by the GenomeStudio Methylation Module. GenomeStudio Software enables researchers to effortlessly perform differential methylation analysis for small-scale studies. It features advanced visualization tools that enable researchers to view vast amounts of data in a single graph, such as heat maps, scatter plots, and line plots.

These tools and the GenomeStudio Genome Browser display valuable information such as chromosomal coordinates, percent GC, location in a CpG Island, and methylation β values.

For large-scale studies, there are many free analysis packages that work in the software framework R for normalization, and differential analysis of methylation data. Instructional videos explain the use of these data analysis packages.

View Manifest (Array Content) Files

Frequently Purchased Together

Specifications

Product Comparison

Infinium MethylationEPIC Kit TruSeq Methyl Capture EPIC Library Prep Kit
Content Specifications Targets 850,000 CpGs. Quantitatively interrogates selected methylation sites across the genome. Targets over 3.3 million CpGs. Interrogates biologically important methylome targets.
Description Quantitative interrogation of selected methylation sites across the genome, offering high-throughput research capabilities at a minimal cost per sample. Focused interrogation of a set of methylome targets for a balanced, cost-effective option that can support both screening studies and biomarker discovery research objectives.
Input Quantity 250 ng DNA 500 ng human genomic DNA
Method Methylation Array Methylation Sequencing , Targeted DNA Sequencing
Number of Samples 8 samples per array Up to 12-plex
Specialized Sample Types FFPE Tissue, Low-Input Samples Not FFPE-Compatible
Species Category Human Human
Technology Microarray Sequencing

Method-Specific Workflow Example

 

The Infinium MethylationEPIC Kit is the recommended replacement product for the HumanMethylation450 BeadChip Kit, which has been discontinued. Illumina remains committed to providing you with high-quality support and service.

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