Human microbiome analysis is the study of microbial communities found in and on the human body. The goal of human microbiome studies is to understand the role of microbes in health and disease.
Traditionally, studying samples from human skin, stool, or blood relied on time- and labor-intensive microbiology techniques of growing and isolating individual organisms followed by phenotypic or genotypic analysis. Microbial community profiling within a single sample was not possible with these methods.
The advent of next-generation sequencing (NGS) enabled several high-profile collaborative projects including the Human Microbiome Project and MetaHIT, which have published a wide range of data on the human microbiome using NGS as a foundational tool.
The throughput and cost savings of NGS have fueled metagenomics studies capable of surveying the genomes of entire communities, including those of unculturable organisms.
This webinar introduces a novel gene-level bioinformatics approach for identifying microbial species and strains associated with human disease from metagenomic sequencing data sets. Samuel Minot, PhD also demonstrates an interactive microbiome discovery portal.Access Webinar
This webinar discusses new sequencing methods, including those generating synthetic long reads, with a focus on their relevance for microbial community analysis. Dr. Stefan J. Green addresses practical approaches to high host and low microbial biomass issues.Access Webinar
The Ribo-Zero Plus rRNA Depletion Kit removes rRNA before RNA-Seq, enabling you to focus on high-value portions of the transcriptome. This technical note demonstrates rRNA depletion performance on microbial isolate and community samples, while comparing against previous kit versions.Read Technical Note
Whole-genome shotgun sequencing and transcriptomics provide researchers and pharmaceutical companies with data to refine drug discovery and development.Read Article
The MiSeq System is enabling the Saca la Lengua project research team to sequence thousands of samples to identify the variety of bacteria and fungi that live in the human mouth.Read Article
Researchers at Microba are investigating the genomes of microbes to improve our understanding of human health, disease, and microbial evolution.Read Article
Learn how human microbes, the community of tiny single-cell organisms living inside our bodies, have a huge—and largely unexplored—impact on our health.View Webinar
The NextSeq 1000 and 2000 Systems empower sequencing for a broad range of current and emerging applications. With over 75 updates, the systems offer dry instrumentation, easier run setup, and fast secondary analysis with DRAGEN software onboard. Experience our simplest workflows yet, and explore the possibilities that exome sequencing, target enrichment, single-cell profiling, and transcriptome sequencing enable.Learn More
Learn how to design microbiome studies that maximize power and chances of success within a given research budget, and better understand how personalized diet-microbiome interactions could be affecting outcomes of your studies.View Webinar
Microbial communities can influence host immune response, affecting cancer progression and treatment efficacy. As NGS-based research continues to explore host–microbiome interactions, there is hope that information about the human microbiome might inform immunotherapeutic strategies.Learn About Cancer Microbiome Studies
Sequencing technologies are enabling a deeper analysis of the gut's microbiome. Researchers can now explore what our microbial inhabitants are doing and how they contribute to, or protect from, disease.Read Article