Infinium Global Screening Array with Cytogenetics-24

Detect structural variation in the human genome and examine cytogenomic changes in constitutional diseases and cancers with this research microarray. Read More...
Select Product(s)

Infinium GSACyto-24 v1.0 Kit, 48 samples (includes array and consumables)

20066469

Infinium GSACyto-24 v1.0 Kit, 288 samples (includes array and consumables)

20066470

Infinium GSACyto-24 v1.0 Kit, 1152 samples (includes array and consumables)

20066471

Services

Infinium® Assay: An Introduction – Customer Site

20015273

Product Highlights

The Infinium Global Screening Array-24 with Cytogenetics-24 v1.0 contains approximately 700K variants, including 80K supplemental probes targeting more than 4800 tiered genes and regions with known disease associations. Target variants were selected based on the input from a cytogenetics research consortium and include genes defined by ClinGen as pathogenic and likely pathogenic along with an enhanced backbone for a modern, up-to-date assay.

  • Detect structural variation in the human genome, including duplications, deletions, amplifications, copy-neutral loss of heterozygosity, and mosaicism.
  • Examine cytogenomic changes in constitutional diseases, cancers, and more.
  • Process sample types including saliva, blood, and buccal swabs using the polymerase chain reaction (PCR)-free Infinium HTS Assay with only 200 ng DNA per sample.
  • Analyze formalin-fixed paraffin-embedded (FFPE) paired tumor-normal samples when used with the appropriate FFPE cluster file.
Broad Clinical Research Applications

Markers were selected from clinical research databases, including ClinVar, CPIC, and PharmGKB for research applications, including risk profiling, pharmacogenomics, wellness characterization, and disease discovery.

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Specifications

Product Comparison

Infinium Global Screening Array with Cytogenetics-24 Infinium Global Diversity Array with Cytogenetics-8 HumanCytoSNP-12 BeadChip
Assay Time 3 days 3 days 3 days
Automation Capability Automated Array Loader, Liquid Handling Robots Automated Array Loader, Liquid Handling Robots Automated Array Loader, Liquid Handling Robots
Cancer Type Hematologic, Solid Tumor Hematologic, Solid Tumor Hematologic, Solid Tumor
Description The 24-sample Infinium Global Screening Array with Cytogenetics-24 provides targeted coverage of more than 4800 key genes across the genome. Approximately 700K markers are included on the BeadChip for high exonic coverage in regions of disease relevance, providing highly accurate copy number variation calls, and an average resolution of 2.5Mb. The 8-sample Infinium Global Diversity Array with Cytogenetics-8 provides extensive targeted coverage of more than 4800 key genes across the genome. Approximately 1.8M markers are included on the BeadChip for high exonic coverage in regions of disease relevance, providing highly accurate copy number variation calls, and an average resolution of 1.5Mb. The 12-sample HumanCytoSNP-12 BeadChip is a whole-genome scanning panel designed for efficient, high-throughput analysis of genetic and structural variations that are relevant to human diseases. The BeadChip incorporates approximately 300K disease-focused markers and markers of known cytogenetic significance.
Hands-On Time 1 hour and 5 minutes for automated 8-beadchip workflow 1 hour and 5 minutes for automated 8-beadchip workflow 1 hour 5 min. for automated 8-beadchip workflow, 6 hours 15 min. for manual 8-beadchip workflow
System Compatibility iScan iScan HiScan, iScan, NextSeq 550
Technology Microarray Microarray Microarray
Variant Class Chromosomal Abnormalities, Copy Number Variants (CNVs), Loss of Heterozygosity (LOH), Single Nucleotide Polymorphisms (SNPs) Chromosomal Abnormalities, Copy Number Variants (CNVs), Loss of Heterozygosity (LOH), Single Nucleotide Polymorphisms (SNPs) Chromosomal Abnormalities, Copy Number Variants (CNVs), Loss of Heterozygosity (LOH), Single Nucleotide Polymorphisms (SNPs)

High-Level Workflow

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