Complex disease research methods

Whole-genome sequencing (WGS)
WGS enables discovery of common variants associated with complex diseases.

Illumina DNA Prep

Human genotyping arrays
Genome-wide genotyping arrays provide a cost-effective solution for common variant discovery through GWAS across and within diverse populations.

Global Screening Array
Global Diversity Array
Asian Screening Array

Whole-genome sequencing (WGS)
WGS enables discovery of common variants associated with complex diseases.

Illumina DNA Prep

Illumina DNA Prep with Enrichment

Targeted genotyping arrays
Targeted arrays enable variant discovery within a particular subset of complex diseases.

Targeted sequencing
Targeted sequencing enables gene variant confirmation as well as novel variant discovery in known genes.

Total RNA-Seq
Total RNA sequencing enables whole-transcriptome analysis including coding and multiple forms of noncoding RNA.

mRNA-Seq
mRNA sequencing enables analysis of coding RNA across the transcriptome for applications such as eQTL mapping.

Single-Cell RNA-Seq
Single-cell RNA sequencing enables whole-transciptome analysis of individual cells, revealing differential responses to environmental stimuli, molecular mechanisms of disease, and interactions in the immune response.

Methylation sequencing
The Illumina 5-base solution enables simultaneous methylation profiling and high-accuracy genetic variant calling.

Illumina 5-Base DNA Prep
Illumina 5-Base DNA Prep with Enrichment

Methylation arrays
Methylation arrays enable cost-effective DNA methylation analysis of coding and noncoding regulatory regions throughout the genome.

ATAC-Seq
Assay for Transposase-Accessible Chromatin using Sequencing (ATAC-Seq) enables interrogation of chromatin accessibility genome-wide.

ChIP-Seq
Chromatin immunoprecipitation sequencing (ChIP-Seq) enables identification of genome-wide DNA binding sites for transcription factors and other proteins.