Public health surveillance is a vital tool for understanding the health of a population and informing public health decision-making.
It involves the systematic collection and analysis of health-related data, which can be used to identify trends and patterns, assess the effectiveness of interventions, and plan and evaluate public health programs.
A central goal of public health is to achieve equity within our communities. By concentrating on community-wide prevention and overall health, public health improves our quality of life, saves money for our communities, helps children thrive, and reduces human suffering.
Genomics can advance public health and wellness by detecting and characterizing new, emerging, and circulating pathogens. By tracking and monitoring infectious agent transmission and disease spread within a community, we can better understand pathogen behavior (infectivity and pathogenicity) and map the evolution of variants. This will ultimately aid the development of diagnostics and design of both therapeutic vaccines and treatments.
The discriminatory power of next-generation sequencing (NGS) is advancing public health surveillance with greater speed, accuracy, and confidence than ever before. Learn more about topics within public health efforts along with diverse solutions offered from Illumina.
Wastewater surveillance allows researchers to monitor outbreaks and other threats by detecting, identifying, and characterizing pathogens in wastewater. This approach can yield important insights such as the spread of diseases for a wide variety of pathogens within a community.
Tuberculosis (TB) surveillance is an important step in addressing the second leading cause of death from infectious disease. Learn how genomics supports public health efforts against tuberculosis through detection, characterization, tracking, and monitoring.
Learn how NGS can identify novel coronavirus mutations, track transmission, study viral genetics, and more with high sensitivity.
Healthcare-associated infections (HAIs) are infections that occur in a healthcare setting and are often caused by multidrug-resistant organisms. These infections can lead to significant morbidity and mortality, increased healthcare costs, and regulatory noncompliance.
Microorganisms can adapt to become resistant to antimicrobial compounds through genomic changes. Learn more about how NGS can detect low-frequency variants and genomic arrangements with unprecedented high-throughput capabilities.
Explore how NGS-based public health surveillance can be used to support three key pillars of pandemic preparedness for infectious diseases: early detection, outbreak response, and clinical research.
Genomic insights using NGS can provide early detection of infectious diseases by:
Infectious disease outbreak responses involve an extensive network of public health professionals. Genomic data from NGS can be used to rapidly characterize pathogens for:
Clinical research plays a central role in identifying and characterizing infectious diseases through the:
Up to 75% of new or emerging infectious diseases are estimated to have zoonotic origins.1,2 We now know that zoonotic reservoirs are significant in the spread of pathogens. With NGS, it is possible to screen reservoir animals such as bats to predict and prevent viral pathogen outbreaks.
Infectious disease surveillance with NGS-methods can help us understand interspecies transmission, how zoonotic diseases emerge, spread and become resistant to common therapies, and enable us to better contain, treat and prevent disease outbreaks.
Hybrid capture sequencing can be scaled up to monitor zoonotic pathogens, while genomic surveillance with metagenomics allows for unbiased, culture-free detection and identification of a broad number of pathogens. Metagenomics also helps us understand the relationship between our microbiome and pathogen interactions, which is important when designing measures to control infectious diseases.
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Genomic Surveillance Methods
See how two new library prep solutions are enabling public health professionals to keep us safe using the proven chemistry from the COVIDSeq workflow. Watch the video to learn how the Illumina Microbial Amplicon Library Prep and the llumina Microbial Amplicon Prep—Influenza A/B are helping build, expand, and improve global genomic surveillance efforts.
Watch Dr. James Wood and Dr. William Haseltine discuss the current state of infectious disease surveillance, its strengths, and shortcomings.
Read how NGS-based methods are revolutionizing high-throughput sequencing for surveillance.
Read this guide from the World Health Organization (WHO) to understand important considerations for developing a national genomic surveillance strategy or action plan for pathogens with pandemic and epidemic potential.
Download this eBook to learn how precision metagenomics is providing innovative solutions to rapidly detect and characterize pathogens through the power of next-generation sequencing.