NextSeq 550Dx

Sequencing capabilities for your clinical applications

The NextSeq 550Dx makes it easy to meet your needs with flexible read lengths and multiple output configurations. Access a growing pipeline of assays with shortened turnaround times, streamlined data analysis, and accuracy, all within a user-friendly interface.

Reproductive health testing

Explore solutions for expecting parents, noninvasive prenatal testing (NIPT), chromosomal analysis for preimplantation genetic screening (PGS), and genetic testing for rare diseases with the NextSeq 550Dx instrument.

Oncology testing

NGS is transforming oncology by offering a more comprehensive and deeper understanding of cancers and tumors. See how to deliver accurate, sensitive, and fast results with the NextSeq 550Dx for oncology testing.

IVD assay development

Customize your NGS-based IVD assays for analysis on the NextSeq 550Dx instrument platform. We’re even collaborating with diagnostic technology partners to expand our menu of clinical assays to help pave the way for more accurate diagnosis, prognosis, and therapeutic options.

For In Vitro Diagnostic Use. Contact an Illumina representative for regional availably.

Empowering genomics-based diagnostics

At Illumina, we are committed to improving human health by unlocking the power of the genome. For more than a decade, we’ve brought our unparalleled expertise as a genomics industry leader to revolutionize healthcare through next-generation sequencing (NGS)-based diagnostics

Download the Dx Platforms Brochure

Efficient clinical workflows for new and emerging applications

The NextSeq 550Dx offers powerful and flexible clinical workflow options in an intuitive system. Take advantage of a broad offering of compliant components or design custom assays for various clinical research applications.

Compare the NextSeq 550Dx and the MiSeqDx systems

Both systems deliver the consistency and reliability of a clinical instrument. Learn how these solutions differ to find the right system for your clinical lab.

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≥120 Gb
output range

≥400 million
reads per run

2 × 150 bp
max read length
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IVD development and testing on the NextSeq 550Dx System*

The Illumina DNA Prep with Enrichment Dx and the NextSeq 550Dx High Output Reagent Kit are IVD reagents and consumables that work together to provide a flexible toolkit for developing and performing diagnostic tests on the NextSeq 550Dx.

Related Products

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Illumina DNA Prep with Enrichment Dx

A library preparation and enrichment solution for in vitro diagnostic (IVD) targeted sequencing applications.

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NextSeq 550Dx Reagents

These sequencing reagent kits offer a simplified workflow and high data quality for in vitro diagnostic testing

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Local Run Manager

Local Run Manager (LRM) software is an integrated solution designed to create sequencing runs, monitor run status, analyze sequencing data, and view results.

*Contact your Illumina representative for more information about IVD development partnerships.

Intended Use for the NextSeq 550Dx

United States:
The NextSeq 550Dx instrument is intended for targeted sequencing of DNA libraries from human genomic DNA extracted from peripheral whole blood or formalin-fixed, paraffin-embedded (FFPE) tissue, when used for in vitro diagnostic (IVD) assays performed on the instrument. The NextSeq 550Dx instrument is not intended for whole genome or de novo sequencing. The NextSeq 550Dx instrument is to be used with specific registered and listed, cleared or approved, IVD reagents and analytical software.

European Union:
The NextSeq 550Dx instrument is intended for sequencing of DNA libraries when used with in vitro diagnostic (IVD) assays performed on the instrument. The NextSeq 550Dx instrument is to be used with specific registered, certified or approved in vitro diagnostic reagents and analytical software.