Robust methylation profiling microarray providing extensive coverage of CpG islands, genes, and enhancers. Ideal for genetic and rare disease research, cancer research, and classification.
Sample throughput
Number of samples
Number of markers
The Infinium MethylationEPIC v2.0 kit is a genome-wide methylation analysis tool targeting ~930K unique methylation sites in the most biologically significant regions of the human methylome.
Genome-wide coverage at a relative affordable cost enables scalable discovery of powerful biological insights into disease mechanisms.
Illumina methylation BeadChips have powered > 10 years of groundbreaking research, with most published epigenome-wide association studies (EWAS) to date completed on MethylationEPIC or its predecessor. Harness methylation data in data repositories like the Gene Expression Omnibus (GEO) or The Cancer Genome Atlas (TCGA).
In addition to whole blood, Methylation EPICv2.0 is also compatible with FFPE sample types, enabling studies to be completed on large biorepositories of tumors.
| Assay type | Infinium HD Methylation |
|---|---|
| Automation capability | Automated array loader |
| Description | The Infinium MethylationEPIC v2.0 BeadChip is a genome-wide methylation analysis tool with enhanced, expert-selected functional content. The kit is processed on the iScan or NextSeq 550 Systems and follows a straightforward, user-friendly workflow that does not require sample pooling and indexing. |
| Input quantity | 250 ng DNA |
| Instruments | NextSeq 550 System, NextSeq 550Dx in Research Mode, iScan System |
| Method | Methylation array |
| Nucleic acid type | DNA |
| Number of markers | ~ 930k |
| Number of samples | 8 samples per array |
| Sample throughput | 3024 samples per week on a single iSCAN |
| Specialized sample types | Blood, FFPE tissue |
| Species category | Human |
| Technology | Microarray |
| Variant class | Differentially methylated cytosines |
Advanced chemistry, optics, and informatics combine to deliver exceptional sequencing speed and data quality, outstanding throughput, and scalability.
Optimized reagent kit that provides increased cluster density and read length, improving sequencing quality scores compared to earlier versions.
Enable CGP with a large pan-cancer panel covering all major variant classes plus gene signatures (TMB, MSI, and HRD) from FFPE tissue.
A fast, integrated workflow for preparing libraries for use in a wide range of sequencing applications.
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