Immunogenomics Research
Immune-Related Genetic Variation
Genomic analysis technologies can advance immunology research by elucidating immune cell function and signaling. The causes of complex autoimmune diseases (such as lupus, rheumatoid arthritis, and multiple sclerosis) and other immunological disorders are still poorly understood.
Immunogenomics solutions from Illumina can help immunology researchers gain insight into potential autoimmune disease mechanisms, the immune repertoire, and the functional consequences of immune-related genetic variation. Next-generation sequencing (NGS) provides the quality, throughput, and read lengths required by the research community to map the immune response at high resolution. Microarrays offer high-density content for large-scale studies of genetic variation in the human immune system.
Immunology Research Review
View summaries of peer-reviewed publications showing the diverse ways in which immunologists use NGS.
Read ReviewNGS in Immune Repertoire Analysis
NGS is proving to be a powerful immunogenomics research tool to map the vast repertoire of immune cells that are capable of recognizing a seemingly boundless array of targets.1 Repertoire sequencing has enabled researchers to identify unique receptor variants found in individuals with susceptibility to autoimmune disorders, hematological malignancies, and other diseases.2
T Cell Receptor Repertoire Analysis
Researchers unravel disease mechanisms by sequencing the T cell receptor (TCR) repertoire as well as mitochondrial DNA and piwi-interacting RNA.
Featured Immunogenomics Webinars
Immunology Discoveries at the Single-Cell Level
Hear about immunology research using single-cell sequencing approaches, from single-cell analysis of airway T cells in severe asthma to reactive astrocyte studies and more.
View WebinarSequencing-Based Discoveries in Immunology
Professors from the University of Oxford, Harvard Medical School, and NYU discuss how NGS data has illuminated understanding of atypical immune cell populations and tissue-specific immune responses.
View WebinarUsing Single-Cell Technologies and Multiomics to Drive Deeper Immune Discoveries
See how multiomic analysis with single-cell tools allowed the discovery of new biomarkers in rare immune cell types and led to high content flow cytometry characterization experiments.
View WebinarUsing Immunogenomics to Decode the Anti-Tumor T-Cell Repertoire
Kellie Smith, PhD, Assistant Professor at Johns Hopkins University, discusses the interplay of cancer neoantigens with the immune response.
View WebinarImmunogenomics Research Articles
Precision Immunotherapies Using Tumor-Specific HLA Ligands
RNA-Seq and human leukocyte antigen (HLA) typing are increasing the power and efficiency of a target discovery platform.
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HLA Genetics & Autoimmune Disease
Researchers query the genome with NGS and perform high-throughput genotyping to identify novel risk loci for immune-mediated disease.
Read Article
NGS Proves Invaluable for Biomarker Discovery
Researchers use NGS for cancer gene expression analysis, immunology research, and immunotherapy biomarker studies.
Read ArticleFeatured Immunology Research Products
AmpliSeq for Illumina Immune Repertoire Plus, TCR beta Panel: Investigate T cell diversity and clonal expansion by sequencing T cell receptor (TCR) beta chain rearrangements.
AmpliSeq for Illumina TCR beta-SR (Short Read) Panel: FFPE-compatible panel for measuring T cell diversity and clonal expansion in tumor samples by sequencing TCR beta chain rearrangements.
AmpliSeq for Illumina Immune Response Panel: Targeted RNA expression panel investigating 395 genes involved in tumor-immune system interactions.
NextSeq 1000 and NextSeq 2000 Systems: These benchtop sequencing systems provide the reads necessary for a detailed view of the immune repertoire and offer extensive cross-application flexibility.
Partek Flow software: This user-friendly software supports analysis and visualization of multiomics data, including V(D)J sequencing data.
Infinium Immunoarray: Evaluate autoimmune disorder and immune function–associated genetic variants on a single microarray.
Infinium Global Screening-24 Kit: Perform scalable, cost-effective population genetics research and study immunology-related variants such as HLA and KIR gene variants.
Single Cell Omics and Cellular Immunology Research
In episode 45 of the Illumina Genomics Podcast, Dr. Shalin Naik discusses the use of single cell genomics to understand the immune system.
Full-length IR-Seq on the NextSeq 1000 and NextSeq 2000 Systems
Learn how the NextSeq 1000 and NextSeq 2000 Systems enable complex immune repertoire sequencing (IR-Seq) studies, including full-length V(D)J sequencing.
Read Application Note
Related Solutions
Tumor Immunogenicity Studies
NGS can help researchers identify mutations that allow tumors to evade the immune response, as well as neoantigens that can boost T cell-mediated immunity. Learn more about immuno-oncology research.
Complex Disease Genomics
Illumina sequencing is introducing new avenues for understanding autoimmune and rheumatic diseases, atherosclerosis, psychiatric, and other disorders on a molecular level. Learn more about complex disease research.
COVID-19 Immune Response Studies
Investigating individual immune system responses to the SARS-CoV-2 virus can increase our understanding of disease susceptibility and severity. Explore methods for studying immunological responses to the virus and identifying genetic risk factors.
Learn More About Immune Response Profiling
Additional Resources
Driving IBD Discovery with Immunogenomics
Dr Carl Anderson discusses integrated research approaches in inflammatory bowel disease (IBD) research.
Unravelling the Mystery of Autoimmunity
Dr. Carola Vinuesa discusses how NGS can unravel the complex interaction of cells and molecules that regulate autoimmunity.
Genomics and Immune Diseases
Dr. Janna Saarela discusses use of genomics to identify mechanisms behind common and rare immune diseases.
Cancer-specific protein patterns of single cells
Quantify and spatially map membrane proteins, and discover immune cell behavior mechanisms.
References
- Woodsworth D.J., Castellarin M., and Holt R.A. Sequence analysis of T-cell repertoires in health and disease. Genome Med. 2013; 5:98.
- Robins H. Immunosequencing: applications of immune repertoire deep sequencing. Curr Opin Immunol. 2013; 25: 646-652.