Multi-Ethnic Genotyping Array Consortium

MEGA Consortia Overview

The Multi-Ethnic Global Array (MEGA) Consortium sought a cost-effective, high-throughput approach for large-scale population research across diverse human populations. Consortium partners designed MEGA microarrays using tagging strategies with the power to detect both common and rare variants in the most commonly studied 5 superpopulations.

Content was leveraged from participating genomics consortia, including the Consortium on Asthma among African-ancestry Populations in the Americas (CAAPA) and the Population Architecture in Genomics and Epidemiology (PAGE) study, to produce arrays with comprehensive multi-ethnic coverage, and updated functional and exome content.

The Expanded Multi-Ethnic Genotyping Array (MEGAEX) was developed to provide extensive genotyping coverage of European, East Asian, and South Asian populations.

Biobanks Use MEGAEX to Analyze Tissue Collections

Personalized medicine programs will combine genomic data with clinical information to gain insight to complex disease.

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Multi-Ethnic Genotyping Array (MEGA) products are now commercially available.
Multi-Ethnic Genotyping Array (MEGA)

MEGA Consortia Participants

Consortium on Asthma among African-ancestry Populations in the Americas (CAAPA)

The CAAPA consortium seeks to facilitate the discovery of genes conferring risk to asthma among individuals of African ancestry, and catalog genetic diversity in populations of African descent, especially those whose ancestry reflects the African Diaspora in the Americas.

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Population Architecture using Genomics and Epidemiology (PAGE)

The PAGE consortium seeks to guide genomic and epidemiologic studies by defining how genetic variants identified through genome-wide association studies (GWAS) are related to a person’s biological and physical characteristics.

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