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    TruSight Cardio Sequencing Panel

    This kit provides researchers with a comprehensive, cost-effective solution for identifying causal variants implicated in inherited cardiac conditions (ICCs).

    TruSight Cardio enrichment oligos are now available separately for use with Illumina DNA Prep with Enrichment. The TruSight Cardio Sequencing Kit for MiSeq and MiSeqDx (FC-141-1010) and TruSight Cardio Sequencing Kits for NextSeq (FC-141-1011 and 20035190) have been discontinued.

    The TruSight Cardiomyopathy Sequencing Panel has been discontinued. The TruSight Cardio Sequencing Kit is the recommended replacement.

    Overview

    The TruSight Cardio Panel uses next-generation sequencing (NGS) to provide comprehensive coverage of 174 genes with known associations to 17 ICCs, including cardiomyopathies, arrhythmias, aortopathies, and more. Genes were expertly selected with researchers at the National Heart Centre Singapore and Imperial College of London. Content includes genes known to be associated with hereditary heart disease and emerging genes found in the literature.1

    • Expertly defined genes selected in collaboration with the Imperial College of London

    • 99% of the targeted regions covered at a depth of at least 20×*

    • Cost to sequence is ~ $1 US per gene; fully supported on Illumina sequencing and informatics platforms

    * Data on file. Illumina, Inc. 2015.

    Specifications

    Content specifications 575 Kb genomic content (174 genes)
    Description Targeted sequencing research panel to identify causal variants associated with 17 inherited cardiac conditions.
    Input quantity 50 ng DNA
    Instruments MiSeq System, NextSeq 550 System, NextSeq 2000 System, NextSeq 1000 System, MiSeqDx in Research Mode, MiniSeq System, NextSeq 500 System
    Method Targeted DNA sequencing, Target enrichment
    Multiplexing Up to 96-plex
    Nucleic acid type DNA
    Specialized sample types Not FFPE-compatible
    Species category Human
    Technology Sequencing
    Variant class Single nucleotide polymorphisms (SNPs), Germline variants

    NovaSeq X Series ordering

    Advanced chemistry, optics, and informatics combine to deliver exceptional sequencing speed and data quality, outstanding throughput, superb scalability.

    MiSeq Reagent Kit v3

    Optimized reagent kit that provides increased cluster density and read length, improving sequencing quality scores compared to earlier versions.

    TruSight Oncology 500

    Enable CGP with a large pan-cancer panel covering all major variant classes plus gene signatures (TMB, MSI, and HRD) from FFPE tissue.

    Illumina DNA Prep

    A fast, integrated workflow for preparing libraries for use in a wide range of sequencing applications.

    References

    1. Pua CJ, Bhalshankar J, Miao K, et al. Development of a comprehensive sequencing assay for inherited cardiac condition genes. J Cardiovasc Trans Res. 2016;9:3.

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