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Advanced chemistry, optics, and informatics combine to deliver exceptional speed and data quality, outstanding throughput and scalability.
Profile clinical research variants associated with congenital disease, cancer research, pharmacogenomics (PGx), and exome content with this microarray.
The Infinium Global Diversity Array with Cytogenetics-8 is a scalable, cost-effective microarray that contains approximately 1.8M probes, with 160K probes supplementing the current Global Diversity Array manifest across more than 4800 tiered genes. Supplemental probes were selected based on the input from a cytogenetics research consortium and strategically localized near exons, in spatial consideration of existing probe placement, to deliver optimal performance in copy number variation analysis.
Markers were selected from clinical research databases, including ClinVar, CPIC, and PharmGKB, for a variety of research applications, including risk profiling, pharmacogenomics, wellness characterization, and disease discovery.
Assay time | 3 days |
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Automation capability | Liquid handling robots, Automated array loader |
Cancer type | Hematologic, Solid tumor |
Description | The 8-sample Infinium Global Diversity Array with Cytogenetics-8 provides extensive targeted coverage of more than 4800 key genes across the genome. Approximately 1.8M markers are included on the BeadChip for high exonic coverage in regions of disease relevance, providing highly accurate copy number variation calls, and an average resolution of 1.5Mb. |
Hands-on time | 1 hour and 5 minutes for automated 8-beadchip workflow |
Input quantity | 200 ng DNA |
Instruments | iScan System |
Method | Cytogenomic array, Genome-wide genotyping array |
Nucleic acid type | DNA |
Number of samples | 8 samples per array |
Specialized sample types | Blood, FFPE tissue, Buccal swabs, Saliva |
Species category | Human |
Technology | Microarray |
Variant class | Single nucleotide polymorphisms (SNPs), Loss of heterozygosity (LOH), Chromosomal abnormalities, Copy number variants (CNVs) |
Infinium Global Diversity Array with Cytogenetics-8
Chromosomal microarray analysis
Chromosomal microarrays reliably detect copy number and allelic contribution imbalances associated with constitutional disorders.
Together, next-generation sequencing and arrays enable cytogenomic analysis of chromosome aberrations for constitutional and cancer research.
Copy number variation analysis
Perform high-resolution copy number variation (CNV) analysis with Illumina array and next-generation sequencing solutions.
Infinium Global Diversity Array with Cytogenetics-8 | Infinium Global Diversity Array-8 Kit | Infinium CytoSNP-850K BeadChip | |
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Assay time | 3 days | 3 days | |
Automation capability | Liquid handling robots, Automated array loader | Liquid handling robots, Automated array loader | Liquid handling robots, Automated array loader |
Cancer type | Hematologic, Solid tumor | Hematologic, Solid tumor | |
Description | The 8-sample Infinium Global Diversity Array with Cytogenetics-8 provides extensive targeted coverage of more than 4800 key genes across the genome. Approximately 1.8M markers are included on the BeadChip for high exonic coverage in regions of disease relevance, providing highly accurate copy number variation calls, and an average resolution of 1.5Mb. | The 8-sample Infinium Diversity Array provides targeted coverage of more than 4800 key genes across the genome. Approximately 1.8M markers are included on the BeadChip for high exonic coverage in regions of disease relevance, providing highly accurate copy number variation calls, and an average resolution of 1.5Mb. | The Infinium CytoSNP-850K BeadChip enables high-resolution analysis for discovery of meaningful chromosomal aberrations through disease-focused coverage of 3262 genes of known cytogenetics relevance. |
Hands-on time | 1 hour and 5 minutes for automated 8-beadchip workflow | 1 hr 5 min for automated 8-beadchip workflow, 6 hr 15 min for manual 8-beadchip workflow | |
Input quantity | 200 ng DNA | 200 ng DNA | 200 ng DNA |
Instruments | iScan System | iScan System | NextSeq 550 System, iScan System |
Method | Cytogenomic array, Genome-wide genotyping array | Genome-wide genotyping array | Cytogenomic array, Genome-wide genotyping array |
Nucleic acid type | DNA | DNA | DNA |
Number of samples | 8 samples per array | 8 samples per array | 8 samples per array |
Specialized sample types | Blood, FFPE tissue, Buccal swabs, Saliva | Blood, FFPE tissue, Buccal swabs, Saliva | FFPE tissue, Blood, Saliva |
Species category | Human | Human | Human |
Technology | Microarray | Microarray | Microarray |
Variant class | Single nucleotide polymorphisms (SNPs), Loss of heterozygosity (LOH), Chromosomal abnormalities, Copy number variants (CNVs) | Single nucleotide polymorphisms (SNPs), Loss of heterozygosity (LOH), Chromosomal abnormalities, Structural variants, Copy number variants (CNVs) | Single nucleotide polymorphisms (SNPs), Loss of heterozygosity (LOH), Chromosomal abnormalities, Copy number variants (CNVs) |
Infinium Global Diversity Array with Cytogenetics (8 Samples)
20122861
The Infinium Global Diversity Array with Cytogenetics Content, 8 Samples Kit combines a versatile disease-focused genome-wide backbone with optimized content for advanced cytogenetic analysis. Each BeadChip assays ~1.8M total variants. Each kit contains 1 BeadChip and the necessary reagents for amplifying, fragmenting, hybridizing, labeling, and detecting 8 samples.
Infinium Global Diversity Array with Cytogenetics (16 Samples)
20066507
The Infinium Global Diversity Array with Cytogenetics, 16 Samples Kit combines a versatile disease-focused genome-wide backbone with optimized content for advanced cytogenetic analysis. Each BeadChip assays ~1.8M total variants. Each kit contains 2 BeadChips and the necessary reagents for amplifying, fragmenting, hybridizing, labeling, and detecting 16 samples.
Infinium Global Diversity Array with Cytogenetics (48 Samples)
20066508
The Infinium Global Diversity Array with Cytogenetics, 48 Samples Kit combines a versatile disease-focused genome-wide backbone with optimized content for advanced cytogenetic analysis. Each BeadChip assays ~1.8M total variants. Each kit contains 6 BeadChips and the necessary reagents for amplifying, fragmenting, hybridizing, labeling, and detecting 48 samples.
Infinium Global Diversity Array with Cytogenetics (96 Samples)
20066509
The Infinium Global Diversity Array with Cytogenetics, 96 Samples Kit combines a versatile disease-focused genome-wide backbone with optimized content for advanced cytogenetic analysis. Each BeadChip assays ~1.8M total variants. Each kit contains 12 BeadChips and the necessary reagents for amplifying, fragmenting, hybridizing, labeling, and detecting 96 samples.
Infinium Global Diversity Array with Cytogenetics (384 Samples)
20066510
The Infinium Global Diversity Array with Cytogenetics, 384 Samples Kit combines a versatile disease-focused genome-wide backbone with optimized content for advanced cytogenetic analysis. Each BeadChip assays ~1.8M total variants. Each kit contains 48 BeadChips and the necessary reagents for amplifying, fragmenting, hybridizing, labeling, and detecting 384 samples.
Infinium® Assay: An Introduction – Customer Site
20015273
Three-day, hands-on instruction at customer site to familiarize users with the essential steps in the Infinium protocol. Course provides hands-on training in sample and BeadChip preparation, sample scanning using the iScan System, and primary data evaluation and analysis using array analysis software.
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