20+
analysis pipelines
DRAGEN apps and pipelines
DRAGEN product offerings
Explore DRAGEN apps and toolkits for fast, flexible secondary analysis across NGS workflows
6
deployment platforms
99.9%
analytical sensitivity
On this page: Apps, Pipelines and modules
Preconfigured workflows for common NGS applications
Put DRAGEN algorithms to work in fit-for-purpose, push-button workflows with minimal setup. DRAGEN Apps combine alignment, quality control, variant calling, and other analysis steps into purpose-built workflows designed for specific assays and applications. Generate consistent results without the complexity of building and maintaining custom pipelines.
7 apps
DRAGEN WGS Heme Tumor-Only
Characterize molecular signatures associated with disease classification, molecular subtypes, and biomarker discovery in hematologic malignancy research.
Whole-genome sequencing analysis optimized for research with hematologic malignancy samples, integrating somatic variant calling, CNV, SV, and subtype-specific analyses into a single workflow.
Data analysis type
Somatic
Tumor-only
DRAGEN WGS Tumor Normal
Matched tumor–normal whole genome analysis
Characterize somatic variation and disease-associated genomic alterations using matched tumor-normal analysis.
Paired tumor-normal WGS analysis supporting detection and characterization of SNVs, indels, CNVs, SVs, TMB, MSI, and HLA types in a streamlined workflow.
Data analysis type
Somatic
Tumor–normal Paired
Pillar OncoReveal via DRAGEN Amplicon
Targeted oncology panel analysis
Investigate targeted genomic biomarkers across hematologic and solid tumor research applications.
Integrated analysis supporting variant detection and annotation from targeted amplicon sequencing.
Data analysis type
Somatic
Tumor-only
DRAGEN TruSight Oncology 500
Comprehensive solid tumor profiling
Profile genomic biomarkers for research related to translational oncology and comprehensive tumor characterization.
App-layer analysis for the TruSight Oncology 500 assay, supporting variant calling, TMB, and MSI analysis from a single 500-gene panel.
Data analysis type
Somatic
Tumor-only
DRAGEN TSO 500 ctDNA
Liquid biopsy ctDNA analysis for solid tumors
Detect and study circulating tumor DNA biomarkers for cancer research and longitudinal characterization of molecular changes.
Tailored secondary analysis for the TruSight Oncology 500 ctDNA assay, supporting detection of low-frequency somatic variants in circulating tumor DNA with assay-specific analysis.
Available on DRAGEN Server v3.
Data analysis type
Somatic
Tumor-only
TruPath Genome
Simplified WGS with on-flow cell library preparation
Characterize germline genomic variation to advance research into inherited disease.
Whole-genome sequencing with ~10 minutes of hands-on time. Uses proximity-mapped read technology to provide long-range genomic information and supports detection of SNVs, indels, SVs, CNVs, STRs, and chromosomal abnormalities without conventional library preparation.
Data analysis type
Germline
DRAGEN 5-Base
Simultaneous variant detection and methylation calling
Integrate genomic and epigenomic information to investigate disease-associated heterogeneity.
Extended base calling and variant analysis supporting 5-base sequencing for methylation and epigenomic research, enabling simultaneous SNV, indel, and 5mC methylation calling from a single sequencing run.
Data analysis type
Germline
Choose the right DRAGEN analysis offering
Explore DRAGEN pipelines and modules for secondary analysis workflows across a wide range of genomics applications and feature compatibility with a server on-premises. Pipelines provide analysis for common research workflows, while modules offer individual analysis components that can be used independently or integrated into custom workflows.
Compare capabilities, supported variant types, output metrics, compatible sequencing systems, and availability options with the lists below.
BCL Convert
High-throughput BCL-to-FASTQ conversion and sample demultiplexing.
Deployment options
On-premises server
NovaSeq X Series
NextSeq 1000 & 2000 Systems
MiSeq i100
BaseSpace
BioInsight Platform Core
Software mode
Offering
Module
DRAGEN Germline
Comprehensive germline analysis with multi-genome mapping for Mendelian genetics research.
Deployment options
On-premises server
NovaSeq X Series
NextSeq 1000 & 2000 Systems
BaseSpace
BioInsight Platform Core
Software mode
Bioinformatics outputs
CNV
Indel
Repeat expansions
SNV
SV
Offering
Pipeline
DRAGEN Enrichment
Combines germline and somatic callers for panel and exome enrichment samples. Includes a full suite of enrichment-specific QC metrics.
Deployment options
On-premises server
NovaSeq X Series
NextSeq 1000 & 2000 Systems
BaseSpace
BioInsight Platform Core
Software mode
Bioinformatics outputs
CNV
Indel
SNV
SV
Offering
Pipeline
DRAGEN Somatic
Somatic variant calling for tumor-only and tumor-normal samples, including low VAF variants, FFPE-optimized analysis, and multi-genome mapping.
Deployment options
On-premises server
NovaSeq X Series
NextSeq 1000 & 2000 Systems
BaseSpace
BioInsight Platform Core
Software mode
Bioinformatics outputs
CNV
HLA
Indel
MSI
SNV
SV
TMB
Offering
Pipeline
DRAGEN RNA
Transcriptome analysis including splice-aware alignment, splice junction discovery, and gene expression quantification.
Deployment options
On-premises server
NovaSeq X Series
NextSeq 1000 & 2000 Systems
BaseSpace
BioInsight Platform Core
Bioinformatics outputs
Gene expression counts
Gene fusion
Indel
SNV
Splice variants
Offering
Pipeline
DRAGEN Amplicon
Amplicon sequencing analysis optimized for targeted resequencing assays. Handles primer trimming, alignment, and variant calling.
Deployment options
On-premises server
NextSeq 1000 & 2000 Systems
BaseSpace
BioInsight Platform Core
Bioinformatics outputs
Indel
SNV
Offering
Pipeline
DRAGEN Single-Cell RNA
Cell-level transcriptomic analysis for demultiplexing, cell-barcode and UMI error correction, alignment, and gene expression quantification.
Deployment options
On-premises server
NextSeq 1000 & 2000 Systems
BaseSpace
BioInsight Platform Core
Software mode
Bioinformatics outputs
Cell-by-gene counts
Cluster plots
Offering
Pipeline
DRAGEN ORA Compression
Lossless FASTQ compression achieving up to 5× reduction in storage footprint.
Deployment options
On-premises server
NovaSeq X Series
NextSeq 1000 & 2000 Systems
MiSeq i100
BioInsight Platform Core
Software mode
Offering
Module
DRAGEN Reference Builder
Build DRAGEN-optimized hash tables from any reference genome in FASTA format.
Deployment options
On-premises server
BioInsight Platform Core
Software mode
Offering
Module
DRAGEN Joint Genotyping
Scalable multi-sample analysis supporting joint calling of small variants, SVs, and CNVs, plus ExpansionHunter VCF merging.
Deployment options
On-premises server
NovaSeq X Series
BaseSpace
BioInsight Platform Core
Software mode
Bioinformatics outputs
CNV
Indel
Repeat expansions
SNV
SV
Offering
Pipeline
DRAGEN Methylation
Bisulfite-aware alignment and methyl calling with full methylation metrics. Suitable for WGBS and RRBS protocols.
Deployment options
On-premises server
NovaSeq X Series
BaseSpace
BioInsight Platform Core
Bioinformatics outputs
per-CpG Methylation calls
Offering
Pipeline
DRAGEN Imputation
Low-pass WGS (lpWGS) imputation pipeline. User-friendly and scalable for population genetics and GWAS applications without the cost of deep WGS.
Deployment options
On-premises server
BaseSpace
BioInsight Platform Core
Software mode
Bioinformatics outputs
CNV
Indel
Offering
Pipeline
DRAGEN Metagenomics
Enabled by Kmer classifier; additional tools in development
Kmer-based metagenomic classification for microbial identification and community profiling.
Deployment options
On-premises server
BaseSpace
Bioinformatics outputs
K-mer counts
Taxonomic classification
Offering
Pipeline
Find your analysis path
Our specialists can help you match the right DRAGEN secondary analysis solution for your assay, throughput, and deployment requirements. All products are Research Use Only.
SNV: single nucleotide variant; Indel: insertion/deletion; CNV: copy number variant; SV: structural variant; PGx: pharmacogenomics; VCF: variant call format; GWAS: genome-wide association study; WGBS: whole-genome bisulfite sequencing; RRBS: reduced representation bisulfite sequencing; UMI: unique molecular identifier.
Publications on file.