ACOG NIPT Guidelines

ACOG/SMFM NIPT guideline update

NIPT should be offered regardless of age or risk

The American Society of Obstetricians and Gynecologists (ACOG) and the Society for Maternal-Fetal Medicine (SMFM) released Practice Bulletin 226, “Screening for Fetal Chromosomal Abnormalities,” in October 2020, advocating that all pregnancies be screened with NIPT. This guideline endorses NIPT as the most sensitive and specific prenatal screening option versus traditional screening methods.


"Cell-free DNA screening [NIPT] […] should be discussed and offered to all patients early in pregnancy regardless of maternal age or baseline risk."

"Cell-free DNA [NIPT] is the most sensitive and specific screening test for the common fetal aneuploidies (trisomies 21, 13, and 18) and can be performed at any time after 9-10 weeks of gestation."

—ACOG/SMFM clinical management guidelines for obstetricians and gynecologists

Highlights of ACOG/SMFM practice bulletin

1-page summary of Practice Bulletin 226


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