Immunogenomics Research
Immune-Related Genetic Variation
Genomic analysis technologies can advance immunology research by elucidating immune cell function and signaling. The causes of complex autoimmune diseases (such as lupus, rheumatoid arthritis, and multiple sclerosis) and other immunological disorders are still poorly understood.
Immunogenomics solutions from Illumina can help immunology researchers gain insight into potential autoimmune disease mechanisms, the immune repertoire, and the functional consequences of immune-related genetic variation. Next-generation sequencing (NGS) provides the quality, throughput, and read lengths required by the research community to map the immune response at high resolution. Microarrays offer high-density content for large-scale studies of genetic variation in the human immune system.
Immunology Research Review
View summaries of peer-reviewed publications showing the diverse ways in which immunologists use NGS.
Read ReviewNGS in Immune Repertoire Analysis
NGS is proving to be a powerful immunogenomics research tool to map the vast repertoire of immune cells that are capable of recognizing a seemingly boundless array of targets.1 Repertoire sequencing has enabled researchers to identify unique receptor variants found in individuals with susceptibility to autoimmune disorders, hematological malignancies, and other diseases.2
T Cell Receptor Repertoire Analysis
Researchers unravel disease mechanisms by sequencing the T cell receptor (TCR) repertoire as well as mitochondrial DNA and piwi-interacting RNA.
Immunogenomics Research Articles
Precision Immunotherapies Using Tumor-Specific HLA Ligands
RNA-Seq and human leukocyte antigen (HLA) typing are increasing the power and efficiency of a target discovery platform.
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HLA Genetics & Autoimmune Disease
Researchers query the genome with NGS and perform high-throughput genotyping to identify novel risk loci for immune-mediated disease.
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NGS Proves Invaluable for Biomarker Discovery
Researchers use NGS for cancer gene expression analysis, immunology research, and immunotherapy biomarker studies.
Read ArticleCOVID-19 Immune Response Studies
Investigating individual immune system responses to the SARS-CoV-2 virus can increase our understanding of disease susceptibility and severity. Explore methods for studying immunological responses to the virus and identifying genetic risk factors.
Learn More About Immune Response Profiling
Immunogenomics Webinars
Using Single-Cell Technologies to Drive Deeper Immune Discoveries
See how multi-omic analysis with single-cell tools allowed the discovery of new biomarkers in rare immune cell types, leading to high content flow cytometry characterization experiments.
View WebinarUsing Immunogenomics to Decode the Anti-Tumor T-Cell Repertoire
Kellie Smith, PhD, Assistant Professor of Oncology at Johns Hopkins University School of Medicine, presents her research on understanding the interplay of cancer neoantigens with the immune response.
View WebinarSequencing-Based Discoveries in Immunology
Paul Klenerman (University of Oxford), Shruti Naik (New York University), and Ana Anderson (Harvard Medical School) discuss how NGS data has illuminated understanding of atypical immune cell populations and tissue-specific immune responses.
View Webinar
Featured Immunology Research Products
AmpliSeq for Illumina Immune Repertoire Plus, TCR beta Panel: Investigate T cell diversity and clonal expansion by sequencing T cell receptor (TCR) beta chain rearrangements.
AmpliSeq for Illumina TCR beta-SR (Short Read) Panel: FFPE-compatible panel for measuring T cell diversity and clonal expansion in tumor samples by sequencing TCR beta chain rearrangements.
AmpliSeq for Illumina Immune Response Panel: Targeted RNA expression panel investigating 395 genes involved in tumor-immune system interactions.
Infinium Immunoarray: Evaluate autoimmune disorder and immune function–associated genetic variants on a single microarray.
Single Cell Omics and Cellular Immunology Research
In episode 45 of the Illumina Genomics Podcast, Dr. Shalin Naik discusses the use of single cell genomics to understand the immune system.
Related Solutions
Tumor Immunogenicity Studies
NGS can help researchers identify mutations that allow tumors to evade the immune response, as well as neoantigens that can boost T cell-mediated immunity. Learn more about immuno-oncology research.
Complex Disease Genomics
Illumina sequencing is introducing new avenues for understanding autoimmune and rheumatic diseases, atherosclerosis, psychiatric, and other disorders on a molecular level. Learn more about complex disease research.
Additional Resources
Driving IBD Discovery with Immunogenomics
Dr Carl Anderson discusses integrated research approaches in inflammatory bowel disease (IBD) research.
Unravelling the Mystery of Autoimmunity
Dr. Carola Vinuesa discusses how NGS can unravel the complex interaction of cells and molecules that regulate autoimmunity.
Genomics and Immune Diseases
Dr. Janna Saarela discusses use of genomics to identify mechanisms behind common and rare immune diseases.
Immune repertoire sequencing on NextSeq 1000/2000 Systems
Learn about immune repertoire sequencing and discover how to obtain high-quality reads with more samples per run in this app note.
Cancer-specific protein patterns of single cells
Download this Application Note to learn how to simultaneously quantify and spatially map membrane proteins using Molecular Pixelation powered by Illumina NGS.
References
- Woodsworth D.J., Castellarin M., and Holt R.A. Sequence analysis of T-cell repertoires in health and disease. Genome Med. 2013; 5:98.
- Robins H. Immunosequencing: applications of immune repertoire deep sequencing. Curr Opin Immunol. 2013; 25: 646-652.