Neurogenomics
Genomics in Neuroscience Research
Genomics technologies such as next-generation sequencing (NGS) and microarrays are accelerating neurogenomics research by revealing the mechanisms behind complex neurological diseases such as Alzheimer’s disease, Parkinson's disease, amyotrophic lateral sclerosis (ALS), and psychiatric disorders.
The interplay between heritable and nonheritable mutations, epigenetics, and other factors requires NGS-level analyses to increase our understanding. Arrays facilitate large-scale studies of genetic variants associated with neurological diseases. Illumina offers the NGS and array tools needed to make neurogenomics research possible.
Hear From Neurogenomics Experts
Genetic Contributions of Cognitive Control
Neuroscience researchers use NGS to identify variants for a microarray designed for ADHD, autism, and schizophrenia studies.
Read InterviewAnalyzing Neuronal Identity with Single-Cell Sequencing
Dr. Bosiljka Tasic discusses how single-cell mRNA sequencing is transforming neuronal classification efforts.
Read InterviewNGS for Variant Discovery in Neuroscience Research
Dr. Franco Taroni uses targeted sequencing to uncover novel genomic variants associated with metabolic and neurological disorders.
Read InterviewFeatured Neurogenomics Research Products
- Neuro Consortium Array: Researchers in the neurogenomics community contributed content for this high-density array featuring over 180,000 markers associated with common neurodegenerative diseases.
- Consortia Boosters for Microarrays: Add specialized content to existing Illumina arrays, including predesigned content for neurodegenerative disease and psychiatric disorder research.
- Infinium PsychArray BeadChip: A cost-effective, high-density microarray for large-scale genetic studies focused on psychiatric predisposition and risk.
- Infinium Global Diversity Array with Enhanced PGx: The most comprehensive genotyping microarray on the market for pharmacogenomics research along with polygenic risk score development and genetic disease research.
- Illumina DNA Prep with Enrichment: A fast, integrated workflow for a wide range of target enrichment applications encompassing whole-exome sequencing as well as custom and fixed panels.
- AmpliSeq for Illumina Neurological Research Panel: This sequencing panel assesses 751 genes known to harbor variants affecting brain and nervous system function.
- Kailos Complete Pharmacogenetic Panel: This enrichment-based targeted sequencing research panel covers genes associated with responses to ~100 medications.
Sequencing Data Analysis for Spinal Muscular Atrophy
Scientists developed a bioinformatics tool that detects SMN1 and SMN2 gene copy number based on whole-genome sequencing data, to advance spinal muscular atrophy research.
Neuroscience Webinars
Using Stem Cells to Explore the Genetics of Neuropsychiatric Disease
Integrating whole-genome or exome sequencing with RNA sequencing and methylation array data in stem cells can help identify genes and pathways that play a role in neurological diseases.
View WebinarSpatial Resolution of the Developing Human Cortex
Dr. Jasmine Plummer from Cedars-Sinai Medical Center uses single-cell RNA sequencing and spatial capture technology to reveal spatial resolution of the developing human fetal cortex.
View WebinarPharmacogenomics
Understand how variations in the human genome affect our response to medications. Pharmacogenomics (PGx) research can ultimately help maximize the benefits of treatment plans while reducing health care costs.
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Neurogenomics Podcasts
Genetics of Autism and Psychiatric Disorders
Dr. Jacob Michaelson, Associate Professor of Psychiatry at the University of Iowa, discusses how he uses genomic and computational techniques to study autism and other psychiatric disorders.
Listen NowBrain on Fire and Genomics of Neuroinflammation
Dr. Michael R. Wilson, Assistant Professor of Neurology at the University of California San Francisco, discusses how genomics can shed light on causes of brain inflammation.
Listen NowLarge-Scale Genetic Risk Profiling in Dementia
Experts discuss the genetics of dementia in this podcast episode, hosted by the UK Dementia Research Institute and Illumina.
Listen NowRelated Solutions
Single-Cell RNA Sequencing
Explore gene expression patterns in individual cells within tissues of interest, or investigate the molecular mechanisms behind subpopulation responses to environmental cues.
Learn MoreComplex Disease Research
Genomic technologies are introducing new avenues for understanding the etiology of complex diseases such as Parkinson's, Alzheimer's, autoimmune, and other disorders on a molecular level.
Learn MoreRare Disease Genomics
Find out how whole-genome sequencing and other genomic technologies can help scientists identify genetic variants linked to rare neurological and other disorders.
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Additional Resources
Integrating Genomic Data for Neurobiology Research
Jonathan Mill, PhD and his team use genomics to better understand neuropsychiatric diseases.
Driving ALS Discovery with Neurogenomics
Jan Veldink, PhD shares how integrative genomics helped drive his ALS research and identify NEK1 as an ALS gene.