Complex disease-associated variants are not limited to mutations in the DNA sequence. There are multiple levels of possible sources of variability including transcription and gene expression, and epigenetic modifications. Complex disease research requires the ability to interrogate the genomes, transcriptomes, and epigenomes of multiple individuals across populations to identify genes, gene networks, and pathways that underlie a complex trait. Illumina offers array and NGS solutions and collaborative expertise to support customer success.
Application | Method | Suggested Products |
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Common Variant Discovery |
Whole-genome sequencing (WGS)
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Human genotyping arrays
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Global Screening Array
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Rare Variant Discovery |
WGS
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Whole-exome sequencing (WES)
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Variant Confirmation |
Targeted genotyping arrays
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Targeted sequencing
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AmpliSeq for Illumina Custom DNA Panel
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Gene Expression/Differential Expression |
Total RNA-Seq
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mRNA-Seq
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Single-Cell RNA-Seq
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Methylation Profiling |
Methylation sequencing
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Methylation arrays
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Chromatin Accessibility |
ATAC-Seq
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Transcription Factor Binding |
ChIP-Seq
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Want to learn valuable insights about the single-cell sequencing workflow?
RNA sequencing is empowering transcriptomics like never before. Get the complete picture of gene expression profiling here.