In Vitro Diagnostic (IVD) Instruments

Regulated platforms with stringent performance characteristics for diagnostic use

NovaSeq 6000DX, front view, in dry lab in front of a window

IVD instruments tailored for clinical labs

Explore in vitro diagnostic (IVD) instruments designed for the clinical lab environment. With easy-to-follow workflows and integrated software, Illumina IVD instruments deliver accurate, reliable screening and diagnostic testing results. Clinical labs can develop and perform their own next-generation sequencing (NGS) tests, run predefined gene panels, or pursue a variety of clinical research applications.

Scientist, pipetting into library tube in NovaSeq 6000 cluster reagent cartridge

IVD instrument comparison table

Key applications and methods	MiSeqDx Instrument	NextSeq 550Dx Instrument	NovaSeq 6000Dx Instrument
Key applications in Diagnostic (Dx) Mode	Cystic fibrosis testing IVD assay development Target enrichment Cancer companion diagnostics Future Illumina assays Future partner assays View more applications	Noninvasive prenatal testing (NIPT) Comprehensive genomic profiling (CGP) IVD assay development Target enrichment Future Illumina assays Future partner assays View more applications	Target enrichment IVD assay development Future Illumina assays Future partner assays View more applications
Key applications in Research (RUO) Mode	Targeted gene sequencing (amplicon, gene panel) Metagenomic analysis Small whole-genome sequencing View more research applications	Exome sequencing Targeted gene sequencing (amplicon, gene panel) Whole-transcriptome sequencing Cytogenomic arrays View more research applications	Whole-genome sequencing Whole-transcriptome sequencing Targeted DNA sequencing (high-throughput exome and large custom enrichment panels) Targeted RNA sequencing (exome, custom enrichment panels) Methylation sequencing View more research applications

Key applications and methods

MiSeqDx Instrument

NextSeq 550Dx Instrument

NovaSeq 6000Dx Instrument

Key applications in Diagnostic (Dx) Mode

Cystic fibrosis testing
IVD assay development
Target enrichment
Cancer companion diagnostics
Future Illumina assays
Future partner assays

View more applications

Noninvasive prenatal testing (NIPT)
Comprehensive genomic profiling (CGP)
IVD assay development
Target enrichment
Future Illumina assays
Future partner assays

View more applications

Target enrichment
IVD assay development
Future Illumina assays
Future partner assays

View more applications

Key applications in Research (RUO) Mode

Targeted gene sequencing (amplicon, gene panel)
Metagenomic analysis
Small whole-genome sequencing

View more research applications

Exome sequencing
Targeted gene sequencing (amplicon, gene panel)
Whole-transcriptome sequencing
Cytogenomic arrays

View more research applications

Whole-genome sequencing
Whole-transcriptome sequencing
Targeted DNA sequencing (high-throughput exome and large custom enrichment panels)
Targeted RNA sequencing (exome, custom enrichment panels)
Methylation sequencing

View more research applications

Key specifications (Dx Mode)
Run time	24 hours	< 35 hours	≤ 45 hours
Maximum output per run	≥ 5 Gb^b	≥ 90 Gb^b	≥ 3 Tb^c,d
Maximum paired-end reads per run	≥ 15M	> 300M	≥ 20B
Read length	2 × 150 bp^e	2 × 150 bp	2 × 150 bp

Additional details
Instrument type	Sequencing instrument	Sequencing instrument	Sequencing instrument
Software features^a	Dx Mode: Local Run Manager RUO Mode: Local Run Manager Illumina Connected Analytics On-premises DRAGEN server	Dx Mode: Local Run Manager Dedicated DRAGEN server RUO Mode: Local Run Manager Illumina Connected Analytics On-premises DRAGEN server	Dx Mode: Dedicated DRAGEN server RUO Mode: Dedicated DRAGEN server BaseSpace Sequence Hub Illumina Connected Analytics
Compatible products	See all MiSeqDx products	See all NextSeq 550Dx products	See all NovaSeq 6000Dx products
Automation capability	Laboratory information management systems (LIMS)	RUO Mode: High-throughput library prep automation Laboratory information management systems (LIMS) Hamilton for NIPT	RUO Mode: High-throughput library prep automation Laboratory information management systems (LIMS)
	Explore MiSeqDx Instrument Order	Explore NextSeq 550Dx Instrument Order	Explore NovaSeq 6000Dx Instrument Order

a. A dedicated DRAGEN server is paired with an Illumina sequencing system and can be used to plan secondary analysis as part of a sequencing run using Illumina Run Manager. An on-premises DRAGEN server does not communicate directly with the sequencing system but can ingest and process data from any Illumina sequencing system via a command line

b. MiSeqDx Instrument and NextSeq 550Dx Instrument libraries generated with TruSeq Custom Amplicon Kit Dx.

c. NovaSeq 6000Dx Instrument libraries generated with Illumina DNA Prep with Enrichment Dx.

d. NovaSeq 6000Dx Instrument specifications are based on a single S4 flow cell.

e. Maximum read length for the MiSeqDx Instrument is 2 x 300 bp, depending on the assay used.

The power of Illumina IVD instruments

Built to withstand the rigor and precision of the IVD world, Illumina IVD instruments empower clinical labs to find the answers they need to improve patient outcomes.

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Brochure PDF 4 MB

8 versions

Female scientist, side view, holding single pipette, male scientist working in the background

Reproductive health

From preconception to noninvasive prenatal testing (NIPT), NGS technologies deliver fast, accurate information that can guide prenatal and reproductive care.

NGS in oncology

By providing deeper insights into the molecular underpinnings of tumors, NGS is transforming the future of cancer care and personalized medicine.

Genetic and rare diseases

NGS technologies can help genetic disease researchers identify causative genetic variants and chromosomal aberrations.

Molecular diagnostics

NGS offers the speed and accuracy to enrich human understanding of disease, enabling earlier detection and reducing the time to diagnosis.

Interested in an instrument demo or in speaking with someone?

Get a demo of any Illumina IVD instrument or contact a specialist to get your questions answered. Fill out a request form and we will be in touch shortly.

For every lab, everywhere

NextSeq 1000 and NextSeq 2000 Reagents

NGS Workflow Finder

DRAGEN v4.3 now available on-premises and on-cloud

Illumina Proactive Instrument Performance Service

Do more, faster than ever

Next-generation sequencing for beginners

Next-generation sequencing for beginners

Next-generation sequencing for beginners

Next-generation sequencing for beginners

Next-generation sequencing for beginners

Next-generation sequencing for beginners

Next-generation sequencing for beginners

Celebrate DNA Day with Your Students

Celebrate DNA Day with Your Students

Celebrate DNA Day with Your Students

Celebrate DNA Day with Your Students

Celebrate DNA Day with Your Students

Celebrate DNA Day with Your Students

Celebrate DNA Day with Your Students

For every lab, everywhere

For every lab, everywhere

For every lab, everywhere

For every lab, everywhere

For every lab, everywhere

For every lab, everywhere

For every lab, everywhere

For every lab, everywhere

For every lab, everywhere

For every lab, everywhere

For every lab, everywhere

For every lab, everywhere

For every lab, everywhere

For every lab, everywhere

For every lab, everywhere

For every lab, everywhere

For every lab, everywhere

For every lab, everywhere

For every lab, everywhere

For every lab, everywhere

For every lab, everywhere

For every lab, everywhere

For every lab, everywhere

For every lab, everywhere

For every lab, everywhere

For every lab, everywhere

For every lab, everywhere

For every lab, everywhere

For every lab, everywhere

For every lab, everywhere

For every lab, everywhere

For every lab, everywhere

For every lab, everywhere

For every lab, everywhere

For every lab, everywhere

For every lab, everywhere

For every lab, everywhere

For every lab, everywhere

For every lab, everywhere

For every lab, everywhere

For every lab, everywhere

For every lab, everywhere

For every lab, everywhere

In Vitro Diagnostic (IVD) Instruments

IVD instruments tailored for clinical labs

IVD instrument comparison table

The power of Illumina IVD instruments

Related content

Reproductive health

NGS in oncology

Genetic and rare diseases

Molecular diagnostics

Interested in an instrument demo or in speaking with someone?