Infinium Global Screening Array-24 Kit

Genotyping array providing a scalable, cost-effective solution for population genetics, pharmacogenomics studies, and precision medicine research.

5760

Sample throughput

24 samples per array

Number of samples

654,027 fixed markers. Custom marker add-on capacity: Up to 100K. 

Number of markers

See full details in the specifications table

Overview

The Infinium Global Screening Array-24 BeadChip is an advanced, scalable, and cost-effective solution for population-scale genetic studies.

Key features

  • Multiethnic genome-wide content selected for high imputation accuracy of > 1% across all 26 1000 Genomes Project Populations

  • High-throughput processing of hundreds to thousands of samples per week with a 3-day workflow for population-scale studies

  • Clinical research applications include disease risk profiling studies, pharmacogenomics research, wellness characterization, and complex disease discovery

Optimized global content

Clinical research content in v3.0 includes variants with established disease associations, relevant pharmacogenomics markers, and curated exonic content derived from ClinVar, NHGRI, PharmGKB, and ExAC databases.

Widely adopted

Over 15 million samples of the Global Screening Array have been ordered by researchers, healthcare networks, consumer genomics companies, and genomic service providers.

Broad applications

Precision medicine research initiatives around the world use the Global Screening Array to study disease risk, stratify samples, and incentivize participation across a large variety of clinical applications.


Specifications


Required products

Choose a kit size that matches the number of samples you wish to run at a time. Each kit is processed as a single batch and is not designed to be divided across multiple experiments. If you are processing several low-throughput batches, order multiple small kits.

You can choose to customize your content using  DesignStudio Microarray Assay Designer or select from a list of add-on content available as  consortia boosters. Booster add-on content is available for:

  • Multi-disease (~50,000 SNPs)

  • Common psychiatric disorders (~30,000 SNPs)

  • Direct-to-consumer wellness and lifestyle (~28,000 SNPs)

  • Oncology (~90,000 SNPs) 

Check with your sales rep to confirm availability and pricing.

/ Results

Applications

The Infinium Global Screening Array-24 is a powerful and cost-effective BeadChip for population-scale genetic studies, variant screening, and precision medicine research. It covers an extensive range of diseases, enabling validation of disease associations, risk profiling, preemptive screening research, and pharmacogenomics studies.

Example workflow

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Select content

Infinium Global Screening Array-24 Kit

2
Process and scan arrays
3

Related applications and methods

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Infinium Global Screening Array-24 Kit Infinium Global Diversity Array-8 Kit Infinium Asian Screening Array-24 Kit Infinium Global Screening Array with Cytogenetics-24
Assay type Infinium HTS Infinium LCG Infinium HTS
Automation capability Liquid handling robots, Automated array loader Liquid handling robots, Automated array loader Liquid handling robots, Automated array loader Liquid handling robots, Automated array loader
Description The Infinium Global Screening Array Kit is an economical genotyping array for population-scale genetics, translational research, variant screening studies, and precision medicine research, combining optimized multiethnic genome-wide content, curated clinical research variants, and QC markers. The 8-sample Infinium Diversity Array provides targeted coverage of more than 4800 key genes across the genome. Approximately 1.8M markers are included on the BeadChip for high exonic coverage in regions of disease relevance, providing highly accurate copy number variation calls, and an average resolution of 1.5Mb. Advanced genotyping array that provides a high-value, scalable, and cost-effective solution for population-scale genetic studies, variant screening, and precision medicine research in East and Southeast Asian populations.  The 24-sample Infinium Global Screening Array with Cytogenetics-24 provides targeted coverage of more than 4800 key genes across the genome. Approximately 700K markers are included on the BeadChip for high exonic coverage in regions of disease relevance, providing highly accurate copy number variation calls, and an average resolution of 2.5Mb.
Input quantity 200 ng DNA 200 ng DNA 200 ng gDNA 200 ng DNA
Instruments iScan System iScan System iScan System iScan System
Method High-throughput genotyping array, Genome-wide genotyping array Genome-wide genotyping array High-throughput genotyping array, Genome-wide genotyping array High-throughput genotyping array, Cytogenomic array
Nucleic acid type DNA DNA DNA DNA
Number of markers 654,027 fixed markers. Custom marker add-on capacity: Up to 100K.  1,825,277 fixed markers. Custom marker add-on capacity: Up to 175K. Fixed markers: ~ 660,000, Custom marker add-on capacity up to 50,000
Number of samples 24 samples per array 8 samples per array 24 samples per array 24 samples per array
Sample throughput ~5760 samples per week ~1728 samples per week ~2304 samples per week (estimate assumes 1 iScan System, 1 AutoLoader, 2 Tecan robots, and a 5-day work week) 
Specialized sample types Blood, FFPE tissue, Buccal swabs, Saliva Blood, FFPE tissue, Buccal swabs, Saliva Blood, FFPE tissue Blood, FFPE tissue, Buccal swabs, Saliva
Species category Human Human Human Human
Technology Microarray Microarray Microarray Microarray
Variant class Single nucleotide polymorphisms (SNPs), Structural variants, Copy number variants (CNVs) Single nucleotide polymorphisms (SNPs), Loss of heterozygosity (LOH), Chromosomal abnormalities, Structural variants, Copy number variants (CNVs) Single nucleotide polymorphisms (SNPs), Structural variants, Insertions-deletions (indels), Copy number variants (CNVs) Single nucleotide polymorphisms (SNPs), Loss of heterozygosity (LOH), Chromosomal abnormalities, Copy number variants (CNVs)

Selection tools:

Figures

Infinium Global Screening Array content

Inner pie shows the proportion of the array selected for genome-wide coverage, clinical research, and quality control (QC). Outer ring shows the weighted reference global allele frequency for unique variants present in 1kGP.1 Variants not in 1kGP are labeled. Counts represent unique variants.

Clinical research content on the Global Screening Array

Content was expertly selected from scientifically recognized databases to create a highly informative array for clinical research applications. Variant counts may be subject to change.

Broad spectrum of pharmacogenomics content on the Global Screening Array

Selected based on CPIC guidelines and PharmGKB database.2 PGx public database variants, variants annotated in PharmGKB, PharmVar, CPIC; Genome-wide PGx coverage, includes markers located in an extended ADME genes or CPIC level A genes including targeted imputation tag SNPs and CPIC level A CNV tags.

Extensive range of disease categories covered on the Global Screening Array

Global Diversity Array clinical research content features markers across a broad range of disease categories based on the NHGRI database.

(A) Variants sorted by range of pathology classifications according to ClinVar American College of Medical Genetics (ACMG) annotations.

(B) Global Diversity Array clinical research content by category within the ClinVar database. Variant counts may be subject to change. 

Resources

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Learn about population-scale applications enabled by the cost-effective high-throughput Infinium microarrays.

Fixed content (3)

Infinium Global Screening Array-24 v3.0 Kit (48 Samples)

20030770

The Infinium Global Screening Array-24 v3.0 combines highly optimized, universal genome-wide backbone, expertly selected clinical research variants, and sample tracking content to create a highly economical array for population-scale genomics and screening. Each Kit contains 2 BeadChips, along with reagents for amplifying, fragmenting, hybridizing, labeling and detecting 48 DNA samples.

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Infinium Global Screening Array-24 v3.0 Kit (288 Samples)

20030771

The Infinium Global Screening Array-24 v3.0 combines highly optimized, universal genome-wide backbone, expertly selected clinical research variants, and sample tracking content to create a highly economical array for population-scale genomics and screening. Each Kit contains 12 BeadChips, along with reagents for amplifying, fragmenting, hybridizing, labeling and detecting 288 DNA samples.

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Infinium Global Screening Array-24 v3.0 Kit (1152 Samples)

20030772

The Infinium Global Screening Array-24 v3.0 combines highly optimized, universal genome-wide backbone, expertly selected clinical research variants, and sample tracking content to create a highly economical array for population-scale genomics and screening. Each Kit contains 48 BeadChips, along with reagents for amplifying, fragmenting, hybridizing, labeling and detecting 1152 DNA samples.

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Add-on content (5)

Infinium Global Screening Array-24+ v3.0 Kit (48 Samples)

20030773

The Infinium Global Screening Array-24 v3.0 combines expertly selected and relevant clinical research variants with a robust genome-wide backbone covering global populations to create a highly economical array for population-scale genomics and screening. Each Kit contains 2 customizable BeadChips, along with reagents for amplifying, fragmenting, hybridizing, labeling and detecting 48 DNA samples

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Infinium Global Screening Array-24+ v3.0 Kit (288 Samples)

20030774

Infinium Global Screening Array-24+ v3.0 Kit (288 Samples)

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Infinium Global Screening Array-24+ v3.0 Kit (1152 Samples)

20030775

The Infinium Global Screening Array-24 v3.0 combines expertly selected and relevant clinical research variants with a robust genome-wide backbone covering global populations to create a highly economical array for population-scale genomics and screening. Each Kit contains 48 customizable BeadChips, along with reagents for amplifying, fragmenting, hybridizing, labeling and detecting 1152 DNA samples.

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Infinium HTSE GSA-24+ v3.0(4,608 Spl)

20034098

Infinium HTSE GSA-24+ v3.0(4,608 Spl)

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Infinium HTSE GSA-24+ v3.0(23,040 Spl)

20034099

Infinium HTSE GSA-24+ v3.0(23,040 Spl)

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Services (1)

Infinium® Assay: An Introduction – Customer Site

20015273

Three-day, hands-on instruction at customer site to familiarize users with the essential steps in the Infinium protocol. Course provides hands-on training in sample and BeadChip preparation, sample scanning using the iScan System, and primary data evaluation and analysis using array analysis software.

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Selection summary

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FAQs

The Global Screening Array is a next-generation genotyping array that combines optimized, multiethnic genome-wide content and clinical research variants for population-scale genetics and screening investigations.

Version 3 of the Infinium Global Screening Array-24 BeadChip is available for research use only. It leverages the most up to date and relevant clinical research screening markers derived from ClinVar, CPIC, and PharmGKB.

The Infinium Global Screening Array uses the highly scalable Infinium HTS format, which provides flexible throughput processing of hundreds to thousands of samples per week. This format provides a rapid 3-day workflow with minimal hands-on time.

The Infinium assay is a high-throughput SNP analysis chemistry that allows identification of SNPs for genotyping and methylation studies. Infinium microarray products have been adopted by a number of leading institutions for population-scale genotyping, epigenome-wide association studies, precision medicine research, and other applications. Learn more about Illumina microarray technology. or explore microarray kits.

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References
  1. The 1000 Genomes Project. http://www.1000genomes.org. Accessed May 20, 2020.
  2. PharmGKB, The Pharmacogenomics Knowledgebase. www.pharmgkb.org. Accessed May 20, 2020.

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