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Info for Health Care Providers

ACOG/SMFM endorses NIPT for all pregnancies regardless of age or riskExplore Updates 

>99% accuracy for trisomies 21, 18, and 13 as early as week 101,2

It's time for NIPT for all

Noninvasive prenatal testing (NIPT), also known as cell-free DNA (cfDNA) screening, is a type of prenatal aneuploidy screening test. With a simple maternal blood draw, NIPT can noninvasively screen for the presence of fetal chromosomal aneuploidies as early as week 10. NIPT is now recommended by the American Society of Obstetricians and Gynecologists (ACOG) and the Society for Maternal-Fetal Medicine (SMFM) for all pregnancies regardless of age or risk.2

Noninvasive

NIPT is as safe and simple as a blood draw.2

Accurate

Gain insights into prenatal genetic health risks with >99% accuracy for trisomies 21, 18, and 13.1

Early

NIPT can be performed as early as week 10 of gestation until term.2

pregnant woman looking at sonogram

Get the facts about NIPT

Download this Fast Facts Sheet to get a quick overview of NIPT, and see how early prenatal genetic insights can help your patients and inform your decision-making process.

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Expanded screening. Expanded insights.

With expanded NIPT, obtain a comprehensive view of all 23 chromosome pairs while limiting risk to your patient. Download this brochure to learn about expanded test options beyond chromosomes 21, 18, and 13.2,3

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Fewer invasive tests mean less maternal and fetal risk

Adopting and implementing NIPT brings several advantages over conventional prenatal serum screening to inform your pregnancy management.4-8

Number of unnecessary invasive procedures for Trisomies 21, 18, AND 13 out of 1000 pregnancies

NIPT

False-positive rate: 0.13%7

~1

unnecessary invasive procedure

vs

Conventional screening

False-positive rate: 4%9

40

unnecessary invasive procedures

Figures shown derived for a hypothetical population of 1000 pregnant women who would receive a false-positive result with each respective test, necessitating confirmatory diagnostic testing.

Hear how peers have incorporated NIPT into their practice

Learn More

These pages are intended for healthcare professional audiences. Some solutions referenced in this content may not be available or approved in specific geographies.

References
  1. Data on file, Illumina, Inc. 2019.
  2. American College of Obstetricians and Gynecologists. Screening for fetal aneuploidy. Practice Bulletin No. 163. Am J Obstet Gynecol. 2016;127(5):e123-e137.
  3. Pertile MD, Halks-Miller M, Flowers N, et al. Rare autosomal trisomies, revealed by maternal plasma DNA sequencing, suggest increased risk of feto-placental disease. Sci Transl Med. 2017;9(405):1-11.
  4. Platt LD, Janicki MB, Prosen T, et al. Impact of noninvasive prenatal testing in regionally dispersed medical centers in the United States. Am J Obstet Gynecol. 2014;211(4):368.e1-368.e7.
  5. Larion S, Warsof SL, Romary L, Mlynarczyk M, Peleg D, Abuhamad AZ. Association of combined first-trimester screen and noninvasive prenatal testing on diagnostic procedures. Obstet Gynecol. 2014;123(6):1303-1310.
  6. Bianchi DW, Parker RL, Wentworth J, et al; for CARE Study Group. DNA sequencing versus standard prenatal aneuploidy screening. N Engl J Med. 2014;370(9):799-808.
  7. Gil MM, Accurti V, Santacruz B, Plana MN, Nicolaides KH. Analysis of cell-free DNA in maternal blood in screening for aneuploidies: updated meta-analysis. Ultrasound Obstet Gynecol. 2017;50:302-314.
  8. Chudova DI, Sehnert AJ, Bianchi DW. Copy-number variation and false positive prenatal screening results. N Engl J Med. 2016;375(1):97-98.
  9. Santorum M, Wright D, Syngelaki A, Karagioti N, Nicolaides KH. Accuracy of first-trimester combined test in screening for trisomies 21, 18 and 13. Ultrasound Obstet Gynecol. 2017;49(6):714-720.