Order the NovaSeq X Series
Advanced chemistry, optics, and informatics combine to deliver exceptional speed and data quality, outstanding throughput and scalability.
Detect structural variation in the human genome and examine cytogenomic changes in constitutional diseases and cancers with this research microarray.
The Infinium Global Screening Array-24 with Cytogenetics-24 contains approximately 700K variants, including 80K supplemental probes targeting more than 4800 tiered genes and regions with known disease associations. Target variants were selected based on the input from a cytogenetics research consortium and include genes defined by ClinGen as pathogenic and likely pathogenic along with an enhanced backbone for a modern, up-to-date assay.
Markers were selected from clinical research databases, including ClinVar, CPIC, and PharmGKB for research applications, including risk profiling, pharmacogenomics, wellness characterization, and disease discovery.
Assay time | 3 days |
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Automation capability | Liquid handling robots, Automated array loader |
Cancer type | Hematologic, Solid tumor |
Description | The 24-sample Infinium Global Screening Array with Cytogenetics-24 provides targeted coverage of more than 4800 key genes across the genome. Approximately 700K markers are included on the BeadChip for high exonic coverage in regions of disease relevance, providing highly accurate copy number variation calls, and an average resolution of 2.5Mb. |
Hands-on time | 1 hour and 5 minutes for automated 8-beadchip workflow |
Input quantity | 200 ng DNA |
Instruments | iScan System |
Method | Cytogenomic array, High-throughput genotyping array |
Nucleic acid type | DNA |
Number of samples | 24 samples per array |
Specialized sample types | Blood, FFPE tissue, Buccal swabs, Saliva |
Species category | Human |
Technology | Microarray |
Variant class | Single nucleotide polymorphisms (SNPs), Loss of heterozygosity (LOH), Chromosomal abnormalities, Copy number variants (CNVs) |
Infinium Global Screening Array with Cytogenetics-24
Chromosomal microarray analysis
Chromosomal microarrays reliably detect copy number and allelic contribution imbalances associated with constitutional disorders.
Together, next-generation sequencing and arrays enable cytogenomic analysis of chromosome aberrations for constitutional and cancer research.
Copy number variation analysis
Perform high-resolution copy number variation (CNV) analysis with Illumina array and next-generation sequencing solutions.
Infinium Global Screening Array with Cytogenetics-24 | Infinium Global Diversity Array with Cytogenetics-8 | |
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Assay time | 3 days | 3 days |
Automation capability | Liquid handling robots, Automated array loader | Liquid handling robots, Automated array loader |
Cancer type | Hematologic, Solid tumor | Hematologic, Solid tumor |
Description | The 24-sample Infinium Global Screening Array with Cytogenetics-24 provides targeted coverage of more than 4800 key genes across the genome. Approximately 700K markers are included on the BeadChip for high exonic coverage in regions of disease relevance, providing highly accurate copy number variation calls, and an average resolution of 2.5Mb. | The 8-sample Infinium Global Diversity Array with Cytogenetics-8 provides extensive targeted coverage of more than 4800 key genes across the genome. Approximately 1.8M markers are included on the BeadChip for high exonic coverage in regions of disease relevance, providing highly accurate copy number variation calls, and an average resolution of 1.5Mb. |
Hands-on time | 1 hour and 5 minutes for automated 8-beadchip workflow | 1 hour and 5 minutes for automated 8-beadchip workflow |
Input quantity | 200 ng DNA | 200 ng DNA |
Instruments | iScan System | iScan System |
Nucleic acid type | DNA | DNA |
Number of samples | 24 samples per array | 8 samples per array |
Specialized sample types | Blood, FFPE tissue, Buccal swabs, Saliva | Blood, FFPE tissue, Buccal swabs, Saliva |
Species category | Human | Human |
Technology | Microarray | Microarray |
Variant class | Single nucleotide polymorphisms (SNPs), Loss of heterozygosity (LOH), Chromosomal abnormalities, Copy number variants (CNVs) | Single nucleotide polymorphisms (SNPs), Loss of heterozygosity (LOH), Chromosomal abnormalities, Copy number variants (CNVs) |
Infinium Global Screening Array with Cytogenetics (24 Samples)
20122862
The Infinium Global Screening Array with Cytogenetics-24, 24 Samples Kit combines a versatile genome-wide backbone with optimized content for advanced cytogenetic analysis. Each BeadChip assays ~700K total variants. The kit contains 1 BeadChip and the necessary reagents for amplifying, fragmenting, hybridizing, labeling, and detecting 24 samples.
Infinium Global Screening Array with Cytogenetics (48 Samples)
20066469
The Infinium Global Screening Array with Cytogenetics-24, 48 Samples Kit combines a versatile genome-wide backbone with optimized content for advanced cytogenetic analysis. Each BeadChip assays ~700K total variants. The kit contains 2 BeadChips and the necessary reagents for amplifying, fragmenting, hybridizing, labeling, and detecting 48 samples.
Infinium Global Screening Array with Cytogenetics (288 Samples)
20066470
The Infinium Global Screening Array with Cytogenetics-24, 288 Samples Kit combines a versatile genome-wide backbone with optimized content for advanced cytogenetic analysis. Each BeadChip assays ~700K total variants. The kit contains 12 BeadChips and the necessary reagents for amplifying, fragmenting, hybridizing, labeling, and detecting 288 samples.
Infinium Global Screening Array with Cytogenetics (1152 Samples)
20066471
The Infinium Global Screening Array with Cytogenetics-24, 1152 Samples Kit combines a versatile genome-wide backbone with optimized content for advanced cytogenetic analysis. Each BeadChip assays ~700K total variants. The kit contains 48 BeadChips and the necessary reagents for amplifying, fragmenting, hybridizing, labeling, and detecting 1152 samples.
Infinium® Assay: An Introduction – Customer Site
20015273
Three-day, hands-on instruction at customer site to familiarize users with the essential steps in the Infinium protocol. Course provides hands-on training in sample and BeadChip preparation, sample scanning using the iScan System, and primary data evaluation and analysis using array analysis software.
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