Molecular epidemiology describes a process of identifying the genetic basis of disease, including variants within hosts and pathogens that influence infection, transmission, and prevention. Researchers determine the sources of infection, route of transmission, and molecular pathways and genes responsible for virulence and drug resistance to support hospital infection control and epidemiological investigations.
Traditional methods of pathogen identification and characterization are often are guided by serial hypotheses and are optimized for a only limited number of organisms.
In combination with extensive epidemiological findings, the portable iSeq 100 System enabled local scientists to analyze transmission patterns and trace the outbreak's origin.Read Article
Illumina NGS helps this lab efficiently detect and track animal and food pathogens.Read Interview
This detailed viral information is enabling public health officials to respond with unprecedented speed and breadth.Read Article
Next-generation sequencing (NGS) allows highly accurate, hypothesis-free analysis of multiple isolates for detection, replacing multiple tests to identify the organism and examine resistance and virulence. High-resolution pathogen typing using whole-genome sequencing data can differentiate organisms that many current methods cannot distinguish.
A key advantage of NGS is that researchers can generate genome sequence data capable of identifying a range of organisms (bacteria, viruses, and parasites). Examining variations across genomes supports cross-sectional studies for better understanding of mechanisms that lead to infection and spread as well as phylogenetic analysis to determine relatedness among organisms.
Microbial whole-genome sequencing is the primary NGS method for molecular epidemiology.
Illumina NGS is uniquely positioned in an infectious disease surveillance and outbreak model. Compare NGS methods and find solutions to detect and characterize SARS-CoV2, track transmission routes, study co-infection, and investigate viral evolution.Learn More
Leveraging next-generation sequencing to detect COVID-19Read Article
Whole-genome shotgun sequencing and transcriptomics provide researchers and pharmaceutical companies with data to refine drug discovery and development.Read Interview
Enables and accelerates research leveraging BaseSpace Correlation EngineRead Article