Regulated reagents for IVD testing and research assays for clinical research

Perform in vitro diagnostic testing and clinical research on the same instrument

NextSeq 550Dx Products & Services

IVD development and testing on the NextSeq 550Dx System*

The TruSeq Custom Amplicon Kit Dx and the NextSeq 550Dx High Output Reagent Kit are IVD reagents and consumables that work together to provide a flexible toolkit for developing and performing diagnostic tests on the NextSeq 550Dx.
TruSeq DNA Exome
TruSeq DNA Exome

This kit provides a low-cost exome sequencing solution that delivers exceptional target coverage over a broad range of read depths.

TruSight One Sequencing Panels
TruSight One Sequencing Panels

Comprehensive sequencing research panels targeting disease-associated regions of the exome with high analytical sensitivity and specificity.

TruSeq Stranded mRNA
TruSeq Stranded mRNA

Prepare sequencing libraries from mRNA to get a clear view of the coding transcriptome with strand-specific information.

TruSight RNA Pan-Cancer
TruSight RNA Pan-Cancer

Targeting 1385 cancer genes for gene expression, variant, and fusion detection studies in many RNA sample types including blood, bone marrow, and formalin-fixed, paraffin-embedded (FFPE) tissue.

NextSeq 500/550 v2.5 Kits
NextSeq 500/550 v2.5 Kits

These sequencing reagent kits offer increased stability and robustness over the v2 kit version.

TruSight Oncology 500
TruSight Oncology 500

Assay targeting multiple variant types, including microsatellite instability (MSI) and tumor mutational burden (TMB).

Illumina Advantage Products

View a list of currently available off-the-shelf Illumina Advantage products tailored to the needs of clinical laboratories.

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Illumina Advantage Products
Local Run Manager (for diagnostic mode only)
Local Run Manager (for diagnostic mode only)

This software provides a user-friendly on-instrument solution for creating sequencing runs, monitoring run status, and analyzing data. It includes a Somatic Variant Module and Germline Variant Module.

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DesignStudio Custom Assay Design Tool

DesignStudio is a web-based assay design tool to help researchers design and order custom sequencing probes, or create custom genotyping array assays.

Sequencing Experiment Setup

Setting up and running sequencing experiments is easy with software tools designed for Illumina sequencing systems.

BaseSpace Sequence Hub

Data management and simplified bioinformatics for labs getting started and for rapidly scaling next-generation sequencing (NGS) operations.

BaseSpace Cohort Analyzer

BaseSpace Cohort Analyzer allows you to integrate and analyze subject and genomic data together using innovative visualization and analysis tools.

BaseSpace Correlation Engine

BaseSpace Correlation Engine mines over 23,000 (and growing) scientific studies to get data-driven answers for genes, experiments, drugs and phenotypes for your research.

BaseSpace Variant Interpreter

BaseSpace Variant Interpreter allows scientists to rapidly identify biologically significant variants from human genomic data.


Illumina services and support begins when the NextSeq 550Dx System is delivered. Illumina scientists and engineers assist with NGS system installation and setup and train laboratory personnel. In addition to on-site support, training courses are available to bring laboratory personnel quickly up to speed.

Illumina scientists are available 24/7 globally to answer questions every step of the way, enabling researchers to focus on making the next breakthrough discovery.

Illumina Product Care

In addition to the 1-year basic service warranty included with system purchase, Illumina offers maintenance, repair, and qualification solutions.

Illumina Training

Get high-quality results on Illumina technology even faster with instructor-led, hands-on courses and web-based training options.

* Contact your Illumina representative for more information about IVD development partnerships

Intended Use for the NextSeq 550Dx

United States:
The NextSeq 550Dx instrument is intended for targeted sequencing of DNA libraries from human genomic DNA extracted from peripheral whole blood or formalin-fixed, paraffin-embedded (FFPE) tissue, when used for in vitro diagnostic (IVD) assays performed on the instrument. The NextSeq 550Dx instrument is not intended for whole genome or de novo sequencing. The NextSeq 550Dx instrument is to be used with registered and listed, cleared or approved, IVD reagents and analytical software.

European Union:
The NextSeq 550Dx instrument is intended for sequencing of DNA libraries when used with in vitro diagnostic (IVD) assays performed on the instrument. The NextSeq 550Dx instrument is to be used with specific registered, certified or approved IVD reagents and analytical software.