Karyomapping: Advancing PGD for Single Gene Disorders
The HumanKaryomap-12 DNA Analysis Kit is a comprehensive genome-wide test available at the single-cell level. It provides insight into the inheritance of single-gene defects.
This BeadChip array targets ~300,000 of the most informative markers in the genome for efficient genome-wide coverage1. Karyomapping uses biomarkers within the genome to assess the likelihood of an embryo carrying a gene variant involved in a single-gene disorder.
The karyomapping technique can create a complete map of the in vitro embryo chromosomes, giving researchers valuable insight into the role that genomics plays in the inheritance of single-gene defects. This method uses SNP (single nucleotide polymorphisms) array technology to confirm the presence or absence of a specific allele.
The SureMDA Amplification System has been discontinued. The REPLI-g Single Cell Kit (QIAGEN) is the suggested replacement for use in karyomapping. Illumina remains committed to providing customers with high-quality support and service.