Making sense of neurological diseases with genomics


Genomics technologies such as next-generation sequencing (NGS) and microarrays are accelerating neurogenomics research by revealing the mechanisms behind complex neurological diseases such as Alzheimer’s disease, Parkinson's disease, amyotrophic lateral sclerosis (ALS), and psychiatric disorders.

The interplay between heritable and nonheritable mutations, epigenetics, and other factors requires NGS-level analyses to increase our understanding. Arrays facilitate large-scale studies of genetic variants associated with neurological diseases. Illumina offers the NGS and array tools needed to make neurogenomics research possible.

Genetic Contributions of Cognitive Control

Neuroscience researchers use NGS to identify variants for a microarray designed for ADHD, autism, and schizophrenia studies.

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Analyzing Neuronal Identity with Single-Cell Sequencing

Dr. Bosiljka Tasic discusses how single-cell mRNA sequencing is transforming neuronal classification efforts.

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NGS for Variant Discovery in Neuroscience Research

Dr. Franco Taroni uses targeted sequencing to uncover novel genomic variants associated with metabolic and neurological disorders.

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Sequencing Data Analysis for Spinal Muscular Atrophy

Scientists developed a bioinformatics tool that detects SMN1 and SMN2 gene copy number based on whole-genome sequencing data, to advance spinal muscular atrophy research.

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Using Stem Cells to Explore the Genetics of Neuropsychiatric Disease
Stem Cells and Neuropsychiatric Disease

Integrating whole-genome or exome sequencing with RNA sequencing and methylation array data in stem cells can help identify genes and pathways that play a role in neurological diseases.

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Spatial Resolution of the Developing Human Cortex

Dr. Jasmine Plummer from Cedars-Sinai Medical Center uses single-cell RNA sequencing and spatial capture technology to reveal spatial resolution of the developing human fetal cortex.

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Understand how variations in the human genome affect our response to medications. Pharmacogenomics (PGx) research can ultimately help maximize the benefits of treatment plans while reducing health care costs.

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Genetics of Autism and Psychiatric Disorders

Dr. Jacob Michaelson, Associate Professor of Psychiatry at the University of Iowa, discusses how he uses genomic and computational techniques to study autism and other psychiatric disorders.

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Brain on Fire and Genomics of Neuroinflammation

Dr. Michael R. Wilson, Assistant Professor of Neurology at the University of California San Francisco, discusses how genomics can shed light on causes of brain inflammation.

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Large-Scale Genetic Risk Profiling in Dementia

Experts discuss the genetics of dementia in this podcast episode, hosted by the UK Dementia Research Institute and Illumina.

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Single-Cell RNA Sequencing

Explore gene expression patterns in individual cells within tissues of interest, or investigate the molecular mechanisms behind subpopulation responses to environmental cues.

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Complex Disease Research

Genomic technologies are introducing new avenues for understanding the etiology of complex diseases such as Parkinson's, Alzheimer's, autoimmune, and other disorders on a molecular level.

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Rare Disease Genomics

Find out how whole-genome sequencing and other genomic technologies can help scientists identify genetic variants linked to rare neurological and other disorders.

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Integrating Genomic Data for Neurobiology Research
Integrating Genomic Data for Neurobiology Research

Jonathan Mill, PhD and his team use genomics to better understand neuropsychiatric diseases.

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Driving ALS Discovery with Integrative Genomics
Driving ALS Discovery with Neurogenomics

Jan Veldink, PhD shares how integrative genomics helped drive his ALS research and identify NEK1 as an ALS gene.

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