Transforming modern infectious disease surveillance

NGS offers a universal, hypothesis-free research method for use with viruses, bacteria, or parasites

Infectious Disease Surveillance and Monitoring

Genomics is transforming modern infectious disease surveillance, expanding our understanding of pathogen evolution, host–pathogen interactions, and antibiotic resistance. In turn, public health professionals are changing the methods they use to protect epidemics and pandemics of high-profile diseases, such as tuberculosis, HIV, and influenza.

Traditional methods of assessing infectious agents include antibody-based testing, real-time PCR, pulsed field gel electrophoresis (PFGE), and multilocus sequence typing (MLST). These methods are typically useful only for a small and defined number of organisms, and data analysis can be subjective.

Human Microbiome Analysis

Next-generation sequencing (NGS) provides a universal, hypothesis-free method for infectious disease surveillance that can be used with viruses, bacteria, or parasites. Genomic analysis with NGS provides high-resolution information to distinguish pathogen strains that differ by as little as one SNP, and it can replace multiple tests.

Illumina NGS technology delivers rapid results and high data quality that public health professionals are adopting to identify, track, and respond to outbreaks.

Adventures in Genomics: Arming the Outposts

In 2014, the world's eyes were pointed toward West Africa, where an Ebola outbreak was claiming the lives of thousands of people. Long before that, however, the Ebola virus was quietly circulating.

To understand how to prevent future outbreaks, we spoke with teams at the Broad Institute and in Sierra Leone. Their work underscores the need for sensitive tools to monitor infectious disease threats.

Read Article
The Fight Against Ebola

The Power and Portability of the iSeq

Local scientists used the iSeq 100 System to analyze transmission patterns and trace the origin of the Ebola outbreak in the Democratic Republic of Congo.

Read Article
Tracking Ebola Outbreaks

Genomic studies with the HiSeq and MiSeq Systems enabled researchers to track Ebola outbreaks and understand the impact of the virus's rapid mutation rate.

Read Interview
Interested in receiving newsletters, case studies, and information on microbial genomics? Enter your email address.
Targeted Sequencing with the Pan-Viral Panel
Targeted Sequencing with the Pan-Viral Panel

Access a streamlined NGS workflow for comprehensive, culture-free detection of viral targets with the iSeq 100 System.

Learn more
Illumina NGS Virology Solutions
Illumina NGS Virology Solutions

Our NGS workflow offers a more complete picture of viruses, host interaction, and other phages specific to microbes.

Access PDF
NGS for Microbial Genomes and Infection Control
NGS for Infection Control

A global collaboration of researchers is using the MiSeq System to understand the evolution and spread of drug-resistant bacteria.

Read Interview
Reconstructing Tuberculosis Outbreaks
Reconstructing Tuberculosis Outbreaks

NGS was used to reconstruct outbreaks of tuberculosis in British Columbia, Canada.

View Video
Deep Sequencing of HIV
Deep Sequencing of HIV

Learn about detection of drug resistance variants and tracking of viral haplotypes.

View Video
Diagnosing Infectious Disease with NGS
Diagnosing Infectious Disease with NGS

Dr Peyro-Saint-Paul explains how the CE-IVD marked iDTECT™ Blood Test can be used to detect pathogens in blood samples.

View Video
Image
HIV Variant Calling

Discover a new streamlined workflow for HIV variant calling.

View Video